晚上一个人看的视频在线播放-MD传媒APP入口免费网址-琪琪视频在线观看-中文字幕人妻A片免费看-强壮的公次次弄得我高潮A片日本-国内精品一卡二卡三卡公司-亚洲精品久久久久久久蜜臀老牛-久久视频在线视频观看:

Regulatory T (T-reg) cells are critical for immune tolerance but also form a barrier to antitumor immunity. As therapeutic strategies involving T-reg cell depletion are limited by concurrent autoimmune disorders, identification of intratumoral T-reg cell-specific regulatory mechanisms is needed for selective targeting. Epigenetic modulators can be targeted with small compounds, but intratumoral T-reg cell-specific epigenetic regulators have been unexplored. Here, we show that JMJD1C, a histone demethylase upregulated by cytokines in the tumor microenvironment, is essential for tumor T-reg cell fitness but dispensable for systemic immune homeostasis. JMJD1C deletion enhanced AKT signals in a manner dependent on histone H3 lysine 9 dimethylation (H3K9me2) demethylase and STAT3 signals independently of H3K9me2 demethylase, leading to robust interferon-gamma production and tumor T-reg cell fragility. We have also developed an oral JMJD1C inhibitor that suppresses tumor growth by targeting intratumoral T-reg cells. Overall, this study identifies JMJD1C as an epigenetic hub that can integrate signals to establish tumor T-reg cell fitness, and we present a specific JMJD1C inhibitor that can target tumor T-reg cells without affecting systemic immune homeostasis.